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Welcome to the website of the Laboratory of Systems and Synthetic Biology, part of the Agrotechnology and Food Sciences Group, Wageningen University
Mission:
Our Mission is to contribute to the elucidation [from a Systems Biology perspective] of the mechanisms underlying basic cellular processes, evolution and interactions among microbes and between microbes and their environment (including the human host) and to translate this knowledge [from a Synthetic Biology perspective] into applications of biotechnological, medical and environmental interest.
Strategic Concept:
Develop and apply theoretical frameworks supporting (and relying on) experimental research towards the understanding of the various processes and hierarchies of cellular networks and circuitry.
Research Activities:
The Systems & Synthetic Biology Laboratory addresses in an integrated way critical issues and novel biotechnological applications in the area Health & Food, Biobased Products and Environment.
We carry out research activities broadly along three major lines:
Computational Systems Biology
Fungal Systems Biology
Synthetic Biology
Publications from 2012 in the spotlight:
Bohlin, J.; Passel, M.W.J. van (2012) Relative entropy differences in bacterial chromosomes, plasmids, phages and genomic islands BMC Genomics 13 . - p. 35.Octrooinummer: 66.
Duuren, J.B.J.H. van; Wijte, D.; Karge, B.; Martins dos Santos, V.A.P.; Yang, Y.; Mars, A.E.; Eggink, G. (2012) pH-stat fed-batch process to enhance the production of cis, cis-muconate from benzoate by Pseudomonas putida KT2440-JD1 Biotechnology Progress 28 (1). - p. 85 - 92.
Lam, M.C.; Suárez Diez, M.; Godinho, M.; Martins dos Santos, V.A.P. (2012) Programmable bacterial catalysis – designing cells for biosynthesis of value-added compounds FEBS Letters.
Leprince, A.; Timmis, K.N.; Martins dos Santos, V.A.P. (2012)
Streamlining of a Pseudomonas putida Genome using a Combinatorial Deletion Method Based on Mini-transposon Insertion and the Flp-FRT Recombination System In: Synthetic Gene Networks / Weber, W., Fussenegger, M., . - Heidelberg : Springer, (Methods in Molecular Biology 813)
à More 2012 publication
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